Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results.


Braga, C; Albuquerque, MdeF; Cordeiro, MT; Castanha, PM; Ramesh, A; Alexander, N; Mello, MJ; Marques, ETJr; Martelli, CM; (2016) Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results. Cadernos de saude publica, 32 (1). ISSN 0102-311X DOI: 10.1590/0102-311X00095815

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Abstract

Dengue cases have increased in younger age groups in Brazil. Maternal anti-dengue antibodies can have a protective effect in the first months of life, but their decline can increase the risk of severe dengue. A prospective birth cohort was established in 2011-2012 in the city of Recife, Pernambuco State, Brazil, to determine the incidence of serotype-specific dengue infection and the kinetics of transferred maternal anti-dengue antibodies in the first years of life. This article describes the design, methods and preliminary results of this cohort study. 354 children underwent clinical and laboratory monitoring for two years, with 15% losses to follow-up. The overall rate of new infections was approximately 10% in the first year of follow-up. Information on the force of serotype-specific dengue infection and the evaluation of transferred maternal antibodies can contribute to understanding dengue etiopathogenesis.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Centre for Statistical Methodology
PubMed ID: 26886185
Web of Science ID: 371569700005
URI: http://researchonline.lshtm.ac.uk/id/eprint/2530992

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