Malaria Vaccine Development: Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity: The West African Merozoite Invasion Network (WAMIN).


WAMIN consortium authors include (in alphabetical order):, ; Ahouidi, AD; Amambua-Ngwa, A; Awandare, GA; Bei, AK; Conway, DJ; Diakite, M; Duraisingh, MT; Rayner, JC; Zenonos, ZA; (2015) Malaria Vaccine Development: Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity: The West African Merozoite Invasion Network (WAMIN). Trends in parasitology. ISSN 1471-4922 DOI: 10.1016/j.pt.2015.11.009

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Abstract

Erythrocyte invasion by Plasmodium falciparum merozoites is an essential step for parasite survival and proliferation. Invasion is mediated by multiple ligands, which could be promising vaccine targets. The usage and sequence of these ligands differs between parasites, yet most studies of them have been carried out in only a few laboratory-adapted lines. To understand the true extent of natural variation in invasion phenotypes and prioritize vaccine candidates on a relevant evidence base, we need to develop and apply standardized assays to large numbers of field isolates. The West African Merozoite Invasion Network (WAMIN) has been formed to meet these goals, expand training in Plasmodium phenotyping, and perform large-scale field phenotyping studies in order to prioritize blood stage vaccine candidates.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Malaria Centre
Vaccine Centre
PubMed ID: 26725306
Web of Science ID: 374610200005
URI: http://researchonline.lshtm.ac.uk/id/eprint/2478786

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