Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges.


Ferrand, RA; Briggs, D; Ferguson, J; Penazzato, M; Armstrong, A; MacPherson, P; Ross, DA; Kranzer, K; (2016) Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges. Tropical medicine & international health , 21 (3). pp. 325-33. ISSN 1360-2276 DOI: 10.1111/tmi.12656

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Abstract

OBJECTIVE: Medication adherence is often suboptimal for adolescents with HIV, and establishing correct weight-based antiretroviral therapy dosing is difficult, contributing to virological failure. This review aimed to determine the proportion of adolescents achieving virological suppression after initiating ART.<br/> METHODS: MEDLINE, EMBASE and Web of Science databases were searched. Studies published between January 2004 and September 2014 including ≥50 adolescents taking ART and reporting on the proportion of virological suppressed participants were included.<br/> RESULTS: From a total of 5316 potentially relevant citations, 20 studies were included. Only eight studies reported the proportion of adolescents that were virologically suppressed at a specified time point. The proportion of adolescents with virological suppression at 12 months ranged from 27 to 89%.<br/> CONCLUSION: Adolescent achievement of HIV virological suppression was highly variable. Improved reporting of virological outcomes from a wider range of settings is required to support efforts to improve HIV care and treatment for adolescents.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 26681359
Web of Science ID: 371509400003
URI: http://researchonline.lshtm.ac.uk/id/eprint/2478671

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