Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians


Jobarteh, M; Malfroy, M; Peterson, I; Jeng, A; Sarge-Njie, R; Alabi, A; Peterson, K; Cotten, M; Hall, A; Rowland-Jones, S; Whittle, H; Tedder, R; Jaye, A; Mendy, M; (2010) Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians. Virology Journal, 7. ISSN 1743-422X DOI: 10.1186/1743-422X-7-230

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Abstract

Background: The prevalence of HIV/hepatitis co-infection in sub-Saharan Africa is not well documented, while both HIV and HBV are endemic in this area. Objective: The aim of this study is to determine the seroprevalence of HBV and HCV virus in HIV-infected subjects in the Gambia. Methods: Plasma samples from HIV infected patients (190 individuals with clinically defined AIDS and 382 individuals without AIDS) were tested retrospectively for the presence of HBV sero-markers and for serum HBV DNA, screened for HCV infection by testing for anti-HCV antibody and HCV RNA. Results: HBsAg prevalence in HIV-positive individuals is 12.2%. HIV/HBV co-infected individuals with CD4 count of < 200 cells uL-1 have a higher HBV DNA viral load than patients with higher CD4 count (log 4.0 vs. log 2.0 DNA copies/ml, p < 0.05). Males (OR = 1.8, 95% CI: 1.0, 3.2) were more likely to be HBsAg positive than female. HCV seroprevalence was 0.9% in HIV-positive individuals. Conclusion: The prevalence of HBsAg carriage in HIV-infected Gambians is similar to that obtained in the general population. However co-infected individuals with reduced CD4 levels, indicative of AIDS had higher prevalence of HBeAg retention and elevated HBV DNA levels compared to non-AIDS patients with higher CD4 count.

Item Type: Article
Keywords: SUB-SAHARAN AFRICA, PREGNANT-WOMEN, HEPATOCELLULAR-CARCINOMA, WEST-AFRICA, HOMOSEXUAL-MEN, GUINEA-BISSAU, CHRONIC CARRIERS, NATURAL-HISTORY, DISEASE BURDEN, LIVER-CANCER
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Vaccine Centre
PubMed ID: 20843322
Web of Science ID: 282606400002
URI: http://researchonline.lshtm.ac.uk/id/eprint/2475

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