The common D302H variant of CASP8 is associated with risk of glioma.


Bethke, L; Sullivan, K; Webb, E; Murray, A; Schoemaker, M; Auvinen, A; Kiuru, A; Salminen, T; Johansen, C; Christensen, HC; Muir, K; McKinney, P; Hepworth, S; Dimitropoulou, P; Lophatananon, A; Feychting, M; Lönn, S; Ahlbom, A; Malmer, B; Henriksson, R; Swerdlow, A; Houlston, R; (2008) The common D302H variant of CASP8 is associated with risk of glioma. Cancer epidemiology, biomarkers & prevention, 17 (4). pp. 987-9. ISSN 1055-9965 DOI: https://doi.org/10.1158/1055-9965.EPI-07-2807

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Abstract

Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and, hence, a defense against cancer. We tested the hypothesis that the CASP8 polymorphism D302H influences risk of glioma through analysis of five series of glioma case patients and controls (n = 1,005 and 1,011, respectively). Carrier status for the rare allele of D302H was associated with a 1.37-fold increased risk (95% confidence interval, 1.10-1.70; P = 0.004). The association of CASP8 D302H with glioma risk indicates the importance of inherited variation in the apoptosis pathway in susceptibility to this form of primary brain tumor.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 18398042
Web of Science ID: 254969000035
URI: http://researchonline.lshtm.ac.uk/id/eprint/2440

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