Serological investigations of flavivirus prevalence in Khammouane Province, Lao People's Democratic Republic, 2007-2008.


Hiscox, A; Winter, CH; Vongphrachanh, P; Sisouk, T; Somoulay, V; Phompida, S; Kaul, S; Sananikhom, P; Nguyen, TY; Paul, RE; Brey, P; Bryant, JE; (2010) Serological investigations of flavivirus prevalence in Khammouane Province, Lao People's Democratic Republic, 2007-2008. The American journal of tropical medicine and hygiene, 83 (5). pp. 1166-9. ISSN 0002-9637 DOI: https://doi.org/10.4269/ajtmh.2010.09-0480

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Abstract

A large-scale cross-sectional seroprevalence study of dengue (DEN) and Japanese encephalitis (JE) was conducted in Khammouane province, Lao PDR, as part of the initial baseline health impact assessment of the Nam Theun 2 hydroelectric dam construction project. Health surveys were performed between May 2007 and February 2008 with serum samples collected from healthy individuals involved in the resettlement program of 16 villages (total surveyed population 4,369). Hemagglutination inhibition assay using flavivirus antigens (DENV1, DENV3, and JEV) performed on 1,708 plasma specimens revealed 30.4% (519) cross-reactive positives, and 10% (172) and 1.3% (22) positives to JEV or DENV, respectively. Entomological surveys conducted during the rainy season of 2008 indicated the presence of competent flavivirus vectors (Culex vishnui group and Aedes albopictus), although Aedes aegypti was not found. Continued surveillance and investigation is warranted to assess the clinical disease burden of flaviviruses in this area that is undergoing rapid ecological and demographic change.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
PubMed ID: 21036856
Web of Science ID: 284184600038
URI: http://researchonline.lshtm.ac.uk/id/eprint/2307

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