Malaria vaccines and the new malaria agenda.


Greenwood, BM; Targett, GA; (2011) Malaria vaccines and the new malaria agenda. Clinical microbiology and infection , 17 (11). pp. 1600-7. ISSN 1198-743X DOI: 10.1111/j.1469-0691.2011.03612.x

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Abstract

: The development of an effective malaria vaccine has taken many decades, but there is now a good chance that the first malaria vaccine will be licensed within the next few years. However, this vaccine (RTS,S) will not be fully effective, and more efficacious, second-generation vaccines will be needed. Good progress is being made in the development of potential vaccines directed at each of the three main stages of the parasite's life cycle, with a variety of different approaches, but many challenges remain, e.g. overcoming the problem of polymorphism in many key parasite antigens. It is likely vaccines that are effective enough to block transmission, and thus contribute to increasing drives towards malaria elimination, will need to contain antigens from different stages of the parasite's life cycle.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
Vaccine Centre
PubMed ID: 21883665
Web of Science ID: 296916300009
URI: http://researchonline.lshtm.ac.uk/id/eprint/224

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