Geographical variation in cardiovascular incidence: results from the British Women's Heart and Health Study.


Kim, LG; Carson, C; Lawlor, DA; Ebrahim, S; (2010) Geographical variation in cardiovascular incidence: results from the British Women's Heart and Health Study. BMC Public Health, 10 (1). p. 696. ISSN 1471-2458 DOI: https://doi.org/10.1186/1471-2458-10-696

[img]
Preview
Text - Published Version
License:

Download (550kB) | Preview

Abstract

ABSTRACT: BACKGROUND: Prevalence of cardiovascular disease (CVD) in women shows regional variations not explained by common risk factors. Analysis of CVD incidence will provide insight into whether there is further divergence between regions with increasing age. METHODS: Seven-year follow-up data on 2685 women aged 59-80 (mean 69) at baseline from 23 towns in the UK were available from the British Women's Heart and Health Study. Time to fatal or non-fatal CVD was analyzed using Cox regression with adjustment for risk factors, using multiple imputation for missing values. RESULTS: Compared to South England, CVD incidence is similar in North England (HR 1.05 (95% CI 0.84, 1.31)) and Scotland (0.93 (0.68, 1.27)), but lower in Midlands / Wales (0.85 (0.64, 1.12)). Event severity influenced regional variation, with South England showing lower fatal incident CVD than other regions, but higher non-fatal incident CVD. Kaplan-Meier plots suggested that regional divergence in CVD occurred before baseline (before mean baseline age of 69). CONCLUSIONS: In women, regional differences in CVD early in adult life do not further diverge in later life. This may be due to regional differences in early detection, survivorship of women entering the study, or event severity. Targeting health care resources for CVD by geographic variation may not be appropriate for older age-groups.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 21078139
Web of Science ID: 284893500001
URI: http://researchonline.lshtm.ac.uk/id/eprint/2212

Statistics


Download activity - last 12 months
Downloads since deposit
190Downloads
297Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item