Effects of maternal and infant co-infections, and of maternal immunisation, on the infant response to BCG and tetanus immunisation.


Elliott, AM; Mawa, PA; Webb, EL; Nampijja, M; Lyadda, N; Bukusuba, J; Kizza, M; Namujju, PB; Nabulime, J; Ndibazza, J; Muwanga, M; Whitworth, JA; (2010) Effects of maternal and infant co-infections, and of maternal immunisation, on the infant response to BCG and tetanus immunisation. Vaccine, 29 (2). pp. 247-55. ISSN 0264-410X DOI: 10.1016/j.vaccine.2010.10.047

[img]
Preview
Text - Published Version
License:

Download (393Kb) | Preview

Abstract

: Some vaccines show poor efficacy in tropical countries. Within a birth cohort in Uganda, we investigated factors that might influence responses to BCG and tetanus immunisation. Whole blood assay responses to crude culture filtrate proteins of Mycobacterium tuberculosis (cCFP)) and tetanus toxoid (TT) were examined among 1506 and 1433 one-year-olds, respectively. Maternal Mansonella perstans infection was associated with higher interleukin (IL)-10 responses to both immunogens but no reduction in gamma interferon (IFN-γ), IL-5 and IL-13 responses; other maternal helminth infections showed little effect. Tetanus immunisation during pregnancy was associated with higher infant responses to TT; maternal BCG scar (from past immunisation) with lower infant IL-5 and IL-13 responses to cCFP. IFN-γ, IL-5 and IL-13 to TT were reduced in HIV-exposed-uninfected infants; infant malaria and HIV were associated with lower IFN-γ, IL-5 and IL-13 responses to both immunogens. We conclude that maternal helminth infections are unlikely to explain poor vaccine efficacy in the tropics. Effects of maternal immunisation on infant responses to vaccines should be explored. Prevention of infant malaria and HIV could contribute to effectiveness of immunisation programmes.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
TB Centre
Vaccine Centre
Tropical Epidemiology Group
PubMed ID: 21040693
Web of Science ID: 287057300013
URI: http://researchonline.lshtm.ac.uk/id/eprint/2195

Statistics


Download activity - last 12 months
Downloads since deposit
233Downloads
358Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item