Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.


Michailidou, K; Beesley, J; Lindstrom, S; Canisius, S; Dennis, J; Lush, MJ; Maranian, MJ; Bolla, MK; Wang, Q; Shah, M; Perkins, BJ; Czene, K; Eriksson, M; Darabi, H; Brand, JS; Bojesen, SE; Nordestgaard, BG; Flyger, H; Nielsen, SF; Rahman, N; Turnbull, C; BOCS, ; Fletcher, O; Peto, J; Gibson, L; dos-Santos-Silva, I; Chang-Claude, J; Flesch-Janys, D; Rudolph, A; Eilber, U; Behrens, S; Nevanlinna, H; Muranen, TA; Aittomäki, K; Blomqvist, C; Khan, S; Aaltonen, K; Ahsan, H; Kibriya, MG; Whittemore, AS; John, EM; Malone, KE; Gammon, MD; Santella, RM; Ursin, G; Makalic, E; Schmidt, DF; Casey, G; Hunter, DJ; Gapstur, SM; Gaudet, MM; Diver, WR; Haiman, CA; Schumacher, F; Henderson, BE; Le Marchand, L; Berg, CD; Chanock, SJ; Figueroa, J; Hoover, RN; Lambrechts, D; Neven, P; Wildiers, H; van Limbergen, E; Schmidt, MK; Broeks, A; Verhoef, S; Cornelissen, S; Couch, FJ; Olson, JE; Hallberg, E; Vachon, C; Waisfisz, Q; Meijers-Heijboer, H; Adank, MA; van der Luijt, RB; Li, J; Liu, J; Humphreys, K; Kang, D; Choi, JY; Park, SK; Yoo, KY; Matsuo, K; Ito, H; Iwata, H; Tajima, K; Guénel, P; Truong, T; Mulot, C; Sanchez, M; Burwinkel, B; Marme, F; Surowy, H; Sohn, C; Wu, AH; Tseng, CC; Van Den Berg, D; Stram, DO; González-Neira, A; Benitez, J; Zamora, MP; Perez, JI; Shu, XO; Lu, W; Gao, YT; Cai, H; Cox, A; Cross, SS; Reed, MW; Andrulis, IL; Knight, JA; Glendon, G; Mulligan, AM; Sawyer, EJ; Tomlinson, I; Kerin, MJ; Miller, N; kConFab Investigators, ; AOCS Group, ; Lindblom, A; Margolin, S; Teo, SH; Yip, CH; Taib, NA; Tan, GH; Hooning, MJ; Hollestelle, A; Martens, JW; Collée, JM; Blot, W; Signorello, LB; Cai, Q; Hopper, JL; Southey, MC; Tsimiklis, H; Apicella, C; Shen, CY; Hsiung, CN; Wu, PE; Hou, MF; Kristensen, VN; Nord, S; Alnaes, GI; NBCS, ; Giles, GG; Milne, RL; McLean, C; Canzian, F; Trichopoulos, D; Peeters, P; Lund, E; Sund, M; Khaw, KT; Gunter, MJ; Palli, D; Mortensen, LM; Dossus, L; Huerta, JM; Meindl, A; Schmutzler, RK; Sutter, C; Yang, R; Muir, K; Lophatananon, A; Stewart-Brown, S; Siriwanarangsan, P; Hartman, M; Miao, H; Chia, KS; Chan, CW; Fasching, PA; Hein, A; Beckmann, MW; Haeberle, L; Brenner, H; Dieffenbach, AK; Arndt, V; Stegmaier, C; Ashworth, A; Orr, N; Schoemaker, MJ; Swerdlow, AJ; Brinton, L; Garcia-Closas, M; Zheng, W; Halverson, SL; Shrubsole, M; Long, J; Goldberg, MS; Labrèche, F; Dumont, M; Winqvist, R; Pylkäs, K; Jukkola-Vuorinen, A; Grip, M; Brauch, H; Hamann, U; Brüning, T; GENICA Network, ; Radice, P; Peterlongo, P; Manoukian, S; Bernard, L; Bogdanova, NV; Dörk, T; Mannermaa, A; Kataja, V; Kosma, VM; Hartikainen, JM; Devilee, P; Tollenaar, RA; Seynaeve, C; Van Asperen, CJ; Jakubowska, A; Lubinski, J; Jaworska, K; Huzarski, T; Sangrajrang, S; Gaborieau, V; Brennan, P; McKay, J; Slager, S; Toland, AE; Ambrosone, CB; Yannoukakos, D; Kabisch, M; Torres, D; Neuhausen, SL; Anton-Culver, H; Luccarini, C; Baynes, C; Ahmed, S; Healey, CS; Tessier, DC; Vincent, D; Bacot, F; Pita, G; Alonso, MR; Álvarez, N; Herrero, D; Simard, J; Pharoah, PP; Kraft, P; Dunning, AM; Chenevix-Trench, G; Hall, P; Easton, DF; , COLLABORATORS; Miedzybrodzka, Z; Morrison, P; Ong, KR; Donaldson, A; Tischkowitz, M; Fryer, A; Berg, J; Porteous, M; Brewer, C; Davidson, R; Kumar, A; Shaw, A; Brady, AF; Adlard, J; Barwell, J; Greenhalgh, L; Evans, G; Lalloo, F; Henderson, A; Shannon, N; Walker, L; Aghmesheh, M; Amor, D; Andrews, L; Antill, Y; Armitage, S; Arnold, L; Balleine, R; Bankier, A; Bastick, P; Beesley, J; Beilby, J; Bennett, B; Bennett, I; Berry, G; Blackburn, A; Bogwitz, M; Brennan, M; Brown, M; Buckley, M; Burgess, M; Burke, J; Butow, P; Byron, K; Callen, D; Campbell, I; Chauhan, D; Chauhan, M; Chenevix-Trench, G; Christian, A; Clarke, C; Colley, A; Cotton, D; Crook, A; Cui, J; Culling, B; Cummings, M; Dawson, SJ; deFazio, A; Delatycki, M; Dickson, R; Dixon, J; Dobrovic, A; Dudding, T; Edkins, T; Edwards, S; Eisenbruch, M; Farshid, G; Fawcett, S; Fellows, A; Fenton, G; Field, M; Firgaira, F; Flanagan, J; Fleming, J; Fong, P; Forbes, J; Fox, S; French, J; Friedlander, M; Gaff, C; Gardner, M; Gattas, M; George, P; Giles, G; Gill, G; Goldblatt, J; Greening, S; Grist, S; Haan, E; Hardie, K; Harris, M; Hart, S; Hayward, N; Healey, S; Heiniger, L; Hopper, J; Humphrey, E; Hunt, C; James, P; Jenkins, M; Jones, A; Kefford, R; Kidd, A; Kiely, B; Kirk, J; Koehler, J; Kollias, J; Kovalenko, S; Lakhani, S; Leaming, A; Leary, J; Lim, J; Lindeman, G; Lipton, L; Lobb, L; Mann, G; Marsh, D; McLachlan, SA; Meiser, B; Meldrum, C; Milne, R; Mitchell, G; Newman, B; Niedermayr, E; Nightingale, S; O'Connell, S; O'Loughlin, I; Osborne, R; Pachter, N; Patterson, B; Peters, L; Phillips, K; Price, M; Purser, L; Reeve, T; Reeve, J; Richards, R; Rickard, E; Robinson, B; Rudzki, B; Saleh, M; Salisbury, E; Sambrook, J; Saunders, C; Saunus, J; Sayer, R; Scott, E; Scott, R; Scott, C; Seshadri, R; Sexton, A; Sharma, R; Shelling, A; Simpson, P; Southey, M; Spurdle, A; Suthers, G; Sykes, P; Tassell, M; Taylor, D; Taylor, J; Thierry, B; Thomas, S; Thompson, E; Thorne, H; Townshend, S; Trainer, A; Tran, L; Tucker, K; Tyler, J; Visvader, J; Walker, L; Walpole, I; Ward, R; Waring, P; Warner, B; Warren, G; Williams, R; Wilson, J; Winship, I; Wu, K; Young, MA; Bowtell, D; Chenevix-Trench, G; Green, A; Webb, P; deFazio, A; Gertig, D; Lo, WY; Justenhoven, C; Ko, YD; Baisch, C; Fischer, HP; Pesch, B; Rabstein, S; Lotz, A; Harth, V; Kleivi, K; Ottestad, L; Kåresen, R; Langerød, A; Schlichting, E; Holmen, MM; Sauer, T; Haakensen, V; Engebråten, O; Naume, B; Kiserud, CE; Reinertsen, KV; Helland, Å, ; Riis, M; Bukholm, I; Lønning, PE; Børresen-Dale, AL; (2015) Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. Nature genetics, 47 (4). pp. 373-80. ISSN 1061-4036 DOI: https://doi.org/10.1038/ng.3242

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Abstract

: Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10(-8). Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be driven by an amino acid substitution encoded in EXO1.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 25751625
Web of Science ID: 351922900013
URI: http://researchonline.lshtm.ac.uk/id/eprint/2130251

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