Novel insights into the protective role of haemoglobin S and C against Plasmodium falciparum parasitaemia.


Mangano, VD; Kabore, Y; Bougouma, EC; Verra, F; Sepulveda, N; Bisseye, C; Santolamazza, F; Avellino, P; Tiono, AB; Diarra, A; Nebie, I; Rockett, KA; Sirima, SB; Modiano, D; MalariaGEN Consortium, ; (2015) Novel insights into the protective role of haemoglobin S and C against Plasmodium falciparum parasitaemia. The Journal of infectious diseases, 212 (4). pp. 626-34. ISSN 0022-1899 DOI: 10.1093/infdis/jiv098

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Abstract

: Although hemoglobin S (HbS) and hemoglobin C (HbC) are well known to protect against severe Plasmodium falciparum malaria, conclusive evidence on their role against infection has not yet been obtained. Here we show, in 2 populations from Burkina Faso (2007-2008), that HbS is associated with a 70% reduction of harboring P. falciparum parasitemia at the heterozygous state (odds ratio [OR] for AS vs AA, 0.27; 95% confidence interval [CI], .11-.66; P = .004). There is no evidence of protection for HbC in the heterozygous state (OR for AC vs AA, 1.49; 95% CI, .69-3.21; P = .31), whereas protection even higher than that observed with AS is observed in the homozygous and double heterozygous states (OR for CC + SC vs AA, 0.04; 95% CI, .01-.29; P = .002). The abnormal display of parasite-adhesive molecules on the surface of HbS and HbC infected erythrocytes, disrupting the pathogenic process of sequestration, might displace the parasite from the deep to the peripheral circulation, promoting its elimination at the spleen level.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 25712976
Web of Science ID: 359677600015
URI: http://researchonline.lshtm.ac.uk/id/eprint/2121415

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