Nocturnal haemoglobin oxygen saturation variability is associated with vitamin C deficiency in Tanzanian children with sickle cell anaemia.


Cox, S; L'esperance, V; Makani, J; Soka, D; Hill, C; Kirkham, F; (2010) Nocturnal haemoglobin oxygen saturation variability is associated with vitamin C deficiency in Tanzanian children with sickle cell anaemia. Acta paediatrica (Oslo, Norway. ISSN 0803-5253 DOI: https://doi.org/10.1111/j.1651-2227.2010.02078.x

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Abstract

Aim:? To compare pulse oximetry in children with sickle cell anaemia (SCA) and controls and test the hypothesis that vitamin C deficiency (VCD; <11.4??mol/L) is associated with nocturnal haemoglobin oxygen desaturation in SCA. Methods:? We undertook nocturnal and daytime pulse oximetry in 23 children with SCA (median age 8?years) with known steady-state plasma vitamin C concentrations and 18 siblings (median 7?years). Results:? Median nocturnal delta 12?s index (delta12?s), a measure of haemoglobin oxygen saturation (SpO(2) ) variability, was 0.38 (interquartile range 0.28-0.51) in SCA and 0.35 (0.23-0.48) in controls, with 9/23 and 6/18, respectively, having a delta12?s >0.4, compatible with obstructive sleep apnoea (OSA). Eleven of twenty-three with SCA had VCD; logged vitamin C concentrations showed a 66% decrease per 0.1 unit increase in delta12?s ([95% CI -86%, -15%]; p?=?0.023) and delta12?s >0.4 was associated with VCD (odds ratio 8.75 [1.24-61.7], p?=?0.029). Daytime and mean nocturnal SpO(2) were lower in SCA but there was no association with vitamin C. Conclusion:? Obstructive sleep apnoea (OSA), detected from nocturnal haemoglobin oxygen saturation variability, is common in Tanzanian children and associated with vitamin C Deficiency in SCA. The direction of causality could be determined by comparing OSA treatment with vitamin C supplementation.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
PubMed ID: 21091961
Web of Science ID: 288451800026
URI: http://researchonline.lshtm.ac.uk/id/eprint/2041

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