The independent effect of living in malaria hotspots on future malaria infection: an observational study from Misungwi, Tanzania.
Mosha, Jacklin F;
Sturrock, Hugh JW;
Brown, Joelle M;
Hashim, Ramadhani;
Kibiki, Gibson;
Chandramohan, Daniel;
Gosling, Roland D;
(2014)
The independent effect of living in malaria hotspots on future malaria infection: an observational study from Misungwi, Tanzania.
Malaria journal, 13 (1).
445-.
ISSN 1475-2875
DOI: https://doi.org/10.1186/1475-2875-13-445
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BACKGROUND: As malaria transmission declines, continued improvements of prevention and control interventions will increasingly rely on accurate knowledge of risk factors and an ability to define high-risk areas and populations at risk for focal targeting of interventions. This paper explores the independent association between living in a hotspot and prospective risk of malaria infection. METHODS: Malaria infection status defined by nPCR and AMA-1 status in year 1 were used to define geographic hotspots using two geospatial statistical methods (SaTScan and Kernel density smoothing). Other malaria risk factors for malaria infection were explored by fitting a multivariable model. RESULTS: This study demonstrated that residing in infection hotspot of malaria transmission is an independent predictor of malaria infection in the future. CONCLUSION: It is likely that targeting such hotspots with better coverage and improved malaria control strategies will result in more cost-efficient uses of resources to move towards malaria elimination.