Smith, Jennifer L; Sturrock, Hugh JW; Assefa, Liya; Nikolay, Birgit; Njenga, Sammy M; Kihara, Jimmy; Mwandawiro, Charles S; Brooker, Simon J; (2014) Factors associated with the performance and cost-effectiveness of using lymphatic filariasis transmission assessment surveys for monitoring soil-transmitted helminths: a case study in Kenya. The American journal of tropical medicine and hygiene, 92 (2). pp. 342-353. ISSN 0002-9637 DOI: https://doi.org/10.4269/ajtmh.14-0435
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Abstract
Transmission assessment surveys (TAS) for lymphatic filariasis have been proposed as a platform to assess the impact of mass drug administration (MDA) on soil-transmitted helminths (STHs). This study used computer simulation and field data from pre- and post-MDA settings across Kenya to evaluate the performance and cost-effectiveness of the TAS design for STH assessment compared with alternative survey designs. Variations in the TAS design and different sample sizes and diagnostic methods were also evaluated. The district-level TAS design correctly classified more districts compared with standard STH designs in pre-MDA settings. Aggregating districts into larger evaluation units in a TAS design decreased performance, whereas age group sampled and sample size had minimal impact. The low diagnostic sensitivity of Kato-Katz and mini-FLOTAC methods was found to increase misclassification. We recommend using a district-level TAS among children 8-10 years of age to assess STH but suggest that key consideration is given to evaluation unit size.
Item Type | Article |
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Faculty and Department | Faculty of Infectious and Tropical Diseases > Dept of Disease Control |
PubMed ID | 25487730 |
ISI | 349065400030 |
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Filename: Factors Associated with the Performance_GOLD VoR.pdf
Licence: Creative Commons: Attribution 3.0
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