Potential for large outbreaks of Ebola virus disease.

Camacho, A; Kucharski, AJ; Funk, S; Breman, J; Piot, P; Edmunds, WJ; (2014) Potential for large outbreaks of Ebola virus disease. Epidemics, 9. pp. 70-8. ISSN 1755-4365 DOI: https://doi.org/10.1016/j.epidem.2014.09.003

Text - Published Version

Download (2MB) | Preview
[img] Text - Supplemental Material

Download (2MB)


Outbreaks of Ebola virus can cause substantial morbidity and mortality in affected regions. The largest outbreak of Ebola to date is currently underway in West Africa, with 3944 cases reported as of 5th September 2014. To develop a better understanding of Ebola transmission dynamics, we revisited data from the first known Ebola outbreak, which occurred in 1976 in Zaire (now Democratic Republic of Congo). By fitting a mathematical model to time series stratified by disease onset, outcome and source of infection, we were able to estimate several epidemiological quantities that have previously proved challenging to measure, including the contribution of hospital and community infection to transmission. We found evidence that transmission decreased considerably before the closure of the hospital, suggesting that the decline of the outbreak was most likely the result of changes in host behaviour. Our analysis suggests that the person-to-person reproduction number was 1.34 (95% CI: 0.92-2.11) in the early part of the outbreak. Using stochastic simulations we demonstrate that the same epidemiological conditions that were present in 1976 could have generated a large outbreak purely by chance. At the same time, the relatively high person-to-person basic reproduction number suggests that Ebola would have been difficult to control through hospital-based infection control measures alone.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Academic Services & Administration > Academic Administration
Research Centre: Centre for the Mathematical Modelling of Infectious Diseases
PubMed ID: 25480136
Web of Science ID: 346006500008
URI: http://researchonline.lshtm.ac.uk/id/eprint/2030883


Download activity - last 12 months
Downloads since deposit
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item