Pertussis may be the cause of prolonged cough in adolescents and adults in the interepidemic period.


Pimentel, AM; Baptista, PN; Ximenes, RA; Rodrigues, LC; Magalhães, V; Pert–Pertussis Study Group; Silva, AR; Souza, NF; Matos, DG; Pessoa, AK; , COLLABORATORS; Silva, AR; Souza, NF; de Matos, DG; Pessoa, AK; (2015) Pertussis may be the cause of prolonged cough in adolescents and adults in the interepidemic period. The Brazilian journal of infectious diseases , 19 (1). pp. 43-6. ISSN 1413-8670 DOI: 10.1016/j.bjid.2014.09.001

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Abstract

OBJECTIVE: This study was aimed to evaluate the prevalence of pertussis in adolescents and adults with cough lasting more than 14 days and less than 30 days.<br/> METHODS: This is a prospective observational study in interepidemic period of pertusis. Ten public health outpatient clinics in the city of Recife, Brazil, were randomly selected for the study. The study population consisted of individuals aged 10 years and over with cough that had lasted between 14 and 30 days. Nasopharyngeal swabs were collected for culture and PCR in order to identify Bordetella pertussis. We adopted the Centers for Disease Control and Prevention in the US (CDC) definition of cases of pertussis.<br/> RESULTS: A total of 192 individuals were identified as suspected cases. Their mean age was 40.7 years. Pertussis was confirmed in 10 of the 192 suspected cases, with an estimated prevalence of 5.21% (95% confidence interval 2.03-8.38). All cases met the clinical case definition for pertussis; one suspect had both culture and PCR positive. PCR confirmed 100% of the cases, 7/10 by PCR and 3/10 by epidemiological linkage with a case confirmed by PCR.<br/> CONCLUSION: During an interepidemic period, 1 in 20 cases of prolonged cough had pertussis, suggesting this is an important cause of prolonged cough in adolescents and adults.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
PubMed ID: 25452019
Web of Science ID: 352168700007
URI: http://researchonline.lshtm.ac.uk/id/eprint/2026679

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