Elevated hepcidin at HIV diagnosis is associated with incident tuberculosis in a retrospective cohort study.
Minchella, PA;
Armitage, AE;
Darboe, B;
Jallow, MW;
Drakesmith, H;
Jaye, A;
Prentice, AM;
McDermid, JM;
(2014)
Elevated hepcidin at HIV diagnosis is associated with incident tuberculosis in a retrospective cohort study.
The international journal of tuberculosis and lung disease, 18 (11).
pp. 1337-1339.
ISSN 1027-3719
DOI: https://doi.org/10.5588/ijtld.14.0143
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Hepcidin inhibits ferroportin-mediated iron efflux, leading to intracellular macrophage iron retention, possibly favoring Mycobacterium tuberculosis iron acquisition and tuberculosis (TB) pathogenesis. Plasma hepcidin was measured at human immunodeficiency virus (HIV) diagnosis in a retrospective HIV-prevalent, antiretroviral-naïve African cohort to investigate the association with incident pulmonary and/or extra-pulmonary TB. One hundred ninety-six participants were followed between 5 August 1992 and 1 June 2002, with 32 incident TB cases identified. Greater hepcidin was associated with significantly increased likelihood of TB after a median time to TB of 6 months. Elucidation of iron-related causal mechanisms and time-sensitive biomarkers that identify individual changes in TB risk are needed.
