Drug Resistance Mutations in Drug-Naive HIV Type 1 Subtype C-Infected Individuals from Rural Malawi.


Bansode, V; Drebert, ZJ; Travers, SA; Banda, E; Molesworth, A; Crampin, A; Ngwira, B; French, N; Glynn, JR; McCormack, GP; (2010) Drug Resistance Mutations in Drug-Naive HIV Type 1 Subtype C-Infected Individuals from Rural Malawi. AIDS research and human retroviruses, 27 (4). pp. 439-44. ISSN 0889-2229 DOI: 10.1089/aid.2010.0203

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Abstract

: In this preliminary study we show that in 2008, 3 years after antiretroviral therapy was introduced into the Karonga District, Malawi, a greater than expected number of drug-naive individuals have been infected with HIV-1 subtype C virus harboring major and minor drug resistance mutations (DRMs). From a sample size of 40 reverse transcriptase (RT) consensus sequences from drug-naive individuals we found five showing NRTI and four showing NNRTI mutations with one individual showing both. From 29 protease consensus sequences, again from drug-naive individuals, we found evidence of minor DRMs in three. Additional major and minor DRMs were found in clonal sequences from a number of individuals that were not present in the original consensus sequences. This clearly illustrates the importance of sequencing multiple HIV-1 variants from individuals to fully assess drug resistance.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Antimicrobial Resistance Centre (AMR)
MEIRU
PubMed ID: 20950147
Web of Science ID: 289074400014
URI: http://researchonline.lshtm.ac.uk/id/eprint/2004

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