Circulating B-lymphocytes as potential biomarkers of tuberculosis infection activity.


Sebina, I; Biraro, IA; Dockrell, HM; Elliott, AM; Cose, S; (2014) Circulating B-lymphocytes as potential biomarkers of tuberculosis infection activity. PLoS One, 9 (9). e106796. ISSN 1932-6203 DOI: 10.1371/journal.pone.0106796

[img]
Preview
Text - Published Version
License:

Download (546kB) | Preview

Abstract

Accurate biomarkers of Mycobacterium tuberculosis infection activity would significantly improve early diagnosis, treatment and management of M. tuberculosis infection. We hypothesised that circulating B-lymphocytes may be useful biomarkers of tuberculosis (TB) infection status in highly TB-endemic settings. Ex-vivo and in-vitro mycobacteria-specific B-cell ELISPOT assays were used to examine the plasmablast (PB) and memory B-cell (MBC) responses in the peripheral blood of adult, healthy, community controls (n = 151) and of active TB patients (n = 48) living in Uganda. Frequencies of mycobacteria-specific PBs were markedly higher in active TB patients compared to healthy controls, and, conversely, MBCs were markedly higher in the healthy controls compared to active TB patients. In addition, the community controls with evidence of latent TB infection had higher peripheral blood PB and MBC responses than those without evidence of TB infection. These data demonstrate that peripheral blood B-cell responses are differentially modulated during latent and active M. tuberculosis infection, and suggest that the PB to MBC ratio may be a useful biomarker of TB infection activity.

Item Type: Article
Faculty and Department: Academic Services & Administration > Academic Administration
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: TB Centre
PubMed ID: 25192196
Web of Science ID: 347993600063
URI: http://researchonline.lshtm.ac.uk/id/eprint/1917897

Statistics


Download activity - last 12 months
Downloads since deposit
268Downloads
294Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item