Parasite infection is associated with Kaposi's sarcoma associated herpesvirus (KSHV) in Ugandan women.
Wakeham, K; Webb, EL; Sebina, I; Muhangi, L; Miley, W; Johnson, WT; Ndibazza, J; Elliott, AM; Whitby, D; Newton, R; (2011) Parasite infection is associated with Kaposi's sarcoma associated herpesvirus (KSHV) in Ugandan women. Infect Agent Cancer, 6 (1). p. 15. ISSN 1750-9378 DOI: https://doi.org/10.1186/1750-9378-6-15
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Abstract
BACKGROUND Immune modulation by parasites may influence susceptibility to bacteria and viruses. We examined the association between current parasite infections, HIV and syphilis (measured in blood or stool samples using standard methods) and antibodies against Kaposi's sarcoma herpesvirus (KSHV), measured by ELISA, in 1915 stored plasma samples from pregnant women in Entebbe, Uganda. RESULTS Seroprevalence of KSHV was higher in women with malaria parasitaemia (73% vs 60% p = 0.01), hookworm (67% vs 56% p = 0.001) and Mansonella perstans (69% vs 59% p = 0.05); seroprevalence increased with increasing intensity of hookworm infection (p < 0.001[trend]). No associations were found for HIV, five other parasites or active syphilis. These effects were not explained by socioeconomic status or education. CONCLUSIONS Specific parasite infections are associated with presence of antibodies against KSHV, perhaps mediated via their effect on immune function.
| Item Type: | Article |
|---|---|
| Faculty and Department: | Faculty of Infectious and Tropical Diseases > Dept of Clinical Research Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology |
| Research Centre: | Centre for Global Non-Communicable Diseases (NCDs) Tropical Epidemiology Group |
| PubMed ID: | 21962023 |
| Web of Science ID: | 208796300015 |
| URI: | http://researchonline.lshtm.ac.uk/id/eprint/1898287 |
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