Promiscuous Expression of ?-Tubulin II in Maturing Male and Female Plasmodium falciparum Gametocytes.


Schwank, S; Sutherland, CJ; Drakeley, CJ; (2010) Promiscuous Expression of ?-Tubulin II in Maturing Male and Female Plasmodium falciparum Gametocytes. PLoS One, 5 (12). e14470. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0014470

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Abstract

Antimalarial interventions designed to impact on the transmissible sexual stages of Plasmodium falciparum are evaluated by measurement of peripheral gametocyte carriage in vivo and infectivity to mosquitoes. Drug or vaccine-elicited effects may differentially affect the relative abundance of mature male and female sexual forms, and this can be measured by estimation of sex ratios before and after intervention in vivo and in vitro. Measuring the impact of anti-gametocyte drugs on sexual commitment of immature gametocyte stages in vitro is not currently possible as male and female parasites cannot be distinguished by morphology alone prior to stage IV.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 21209927
Web of Science ID: 285793600012
URI: http://researchonline.lshtm.ac.uk/id/eprint/1811

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