A review of the evidence for dietary interventions in preventing or slowing the progression of age-related macular degeneration.


Evans, JR; Lawrenson, JG; (2014) A review of the evidence for dietary interventions in preventing or slowing the progression of age-related macular degeneration. Ophthalmic & physiological optics, 34 (4). pp. 390-6. ISSN 0275-5408 DOI: https://doi.org/10.1111/opo.12142

Full text not available from this repository. (Request a copy)

Abstract

To summarise the results of recent Cochrane systematic reviews that have investigated whether nutritional supplements prevent or slow the progression of age-related macular degeneration (AMD). There is no good evidence from randomised controlled trials that the general population should be taking antioxidant vitamin supplements to reduce their risk of developing AMD later on in life. By contrast, there is moderate quality evidence that people with AMD may experience a delay in progression by taking specific antioxidant vitamin and mineral supplements. This finding is drawn from one large randomised controlled trial conducted in the USA in a relatively well-nourished population. Although observational studies have shown that the consumption of dietary omega 3 long chain polyunsaturated fatty acids may reduce the risk of progression to advanced AMD, two recently published randomised controlled trials failed to show any benefit of omega 3 supplements on AMD progression. There is no high quality experimental evidence that nutritional supplementation is beneficial for the primary prevention of AMD. However, people with AMD may benefit from supplementation with antioxidant vitamins. There is currently no evidence to support increasing levels of omega 3 long chain polyunsaturated fatty acids in the diet for the explicit purpose of preventing or slowing the progression of AMD.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: The International Centre for Evidence in Disability
International Centre for Eye Health
PubMed ID: 24903538
Web of Science ID: 339486100002
URI: http://researchonline.lshtm.ac.uk/id/eprint/1776623

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
273Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item