Impact of nutritional status on antibody responses to different vaccines in undernourished Gambian children


Moore, SE; Goldblatt, D; Bates, CJ; Prentice, AM; (2003) Impact of nutritional status on antibody responses to different vaccines in undernourished Gambian children. Acta paediatrica (Oslo, Norway, 92 (2). pp. 170-176. ISSN 0803-5253 DOI: https://doi.org/10.1080/713795480

Full text not available from this repository. (Request a copy)

Abstract

Aim: To test the efficacy of T-cell-dependent and T-cell- independent vaccines in rural Gambian children suffering from a range of energy/protein and micronutrient deficiencies. Methods: Nutritional status (anthropometry, haemoglobin, plasma leptin and micronutrient status) and response to two vaccinations (23 valent pneumococcal capsular polysaccharide vaccine, Pneumovax(R) and the Human Diploid-Cell Rabies Vaccine) were assessed in 472 children aged 6 1/2 to 9 1/2 y. Results: Anthropometry and micronutrient status (as z-scores against European reference values) indicated a range from moderate to severe levels of undernutrition [mean (interquartile range): weight-for-age z-score -1.58 (-2.18 to - 0.95); height-for-age z-score -0.94 (-1.51 to -0.35); body- mass-index-for-age z-score -1.43 (-2.05 to -0.84); mid-upper arm circumference -1.41 (=1.72 to -1.13); leptin -1.06 (-1.10 to -1.03); haemoglobin (Hb) -0.30 (-1.18 to 0.79); zinc -1.29 (-2.42 to -0.55); vitamin C -0.01 (-1.18 to 1.15); retinol - 1.33 (-1.97 to -0.77)]. A seasonal effect was observed in haemoglobin levels and in all micronutrients (with the exception of zinc and retinol) and in the response to vaccination. After adjusting for seasonality, age and gender, no consistent associations were found between any of the measures of nutritional status and the effectiveness of seroconversion to either of the vaccines. Conclusion: The successful short-term seroconversion to whole inactivated viral and bacterial polysaccharide vaccines indicates that the processes leading to antibody secretion remain intact over a wide range of single and combined nutrient deficiencies.

Item Type: Article
Keywords: nutritional status, pneumococcus, rabies, The Gambia, vaccine, response, Protein-calorie malnutrition, malnourished children, neutralizing antibody, birth-weight, serum, vaccination, standard
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 12710642
Web of Science ID: 182015500008
URI: http://researchonline.lshtm.ac.uk/id/eprint/17675

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
310Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item