Aetiology of suppurative corneal ulcers in Ghana and south India, and epidemiology of fungal keratitis


Leck, AK; Thomas, PA; Hagan, M; Kaliamurthy, J; Ackuaku, E; John, M; Newman, MJ; Codjoe, FS; Opintan, JA; Kalavathy, CM; Essuman, V; Jesudasan, CA; Johnson, GJ; (2002) Aetiology of suppurative corneal ulcers in Ghana and south India, and epidemiology of fungal keratitis. The British journal of ophthalmology, 86 (11). pp. 1211-5. ISSN 0007-1161 DOI: https://doi.org/10.1136/bjo.86.11.1211

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Abstract

BACKGROUND: A multicentre study was carried out in Ghana and southern India to determine the aetiology of suppurative keratitis in two regions located at similar tropical latitudes. Studies of fungal keratitis from the literature were reviewed. METHODS: Patients presenting at rural and urban eye units with suspected microbial keratitis were recruited to the study. Corneal ulceration was defined as loss of corneal epithelium with clinical evidence of infection with or without hypopyon. Microscopy and culture were performed on all corneal specimens obtained. RESULTS: 1090 patients were recruited with suspected microbial keratitis between June 1999 and May 2001. Overall the principal causative micro-organisms in both regions were filamentous fungi (42%): Fusarium species and Aspergillus species were the commonest fungal isolates. Pseudomonas species were most frequently isolated from cases of bacterial keratitis in Ghana but in India the commonest bacterial isolates were streptococci. CONCLUSION: Infections of the cornea due to filamentous fungi are a frequent cause of corneal damage in developing countries in the tropics and are difficult to treat. Microscopy is an essential tool in the diagnosis of these infections. A knowledge of the "local" aetiology within a region is of value in the management of suppurative keratitis in the event that microscopy cannot be performed.

Item Type: Article
Keywords: Aspergillosis/epidemiology, Corneal Ulcer/epidemiology/*microbiology, Eye Infections, Bacterial/epidemiology, Eye Infections, Fungal/*epidemiology/microbiology, Fusarium, Ghana/epidemiology, Human, India/epidemiology, Keratitis/epidemiology/microbiology, Prevalence, Prospective Studies, Pseudomonas Infections/epidemiology
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 12386069
Web of Science ID: 178812500006
URI: http://researchonline.lshtm.ac.uk/id/eprint/17627

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