Use of spoligotyping for accurate classification of recurrent tuberculosis

Warren, RM; Streicher, EM; Charalambous, S; Churchyard, G; van der Spuy, GD; Grant, A; van Helden, PD; Victor, TC; (2002) Use of spoligotyping for accurate classification of recurrent tuberculosis. Journal of clinical microbiology, 40 (10). pp. 3851-3. ISSN 0095-1137 DOI: 10.1128/jcm.40.10.3851-3851.2002

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Abstract

The spoligotyping method has become an important tool for the tracking of Mycobacterium tuberculosis strains in different epidemiological settings. In this study, we demonstrate the ability of the spoligotyping technique to accurately determine the pathogenetic mechanism of recurrent disease. This methodology has advantages over conventional restriction fragment length polymorphism methods which may be useful in large-scale intervention studies.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: TB Centre
Keywords: Direct repeat locus, mycobacterium-tuberculosis, complex, strains, is6110, epidemiology, differentiation, markers, contamination, polymorphism, element, Comparative Study, Diagnostic Techniques and Procedures, Human, Mycobacterium tuberculosis, classification, genetics, Polymorphism, Restriction Fragment Length, Recurrence, Support, Non-U.S. Gov't, Tuberculosis, diagnosis, microbiology
PubMed ID: 12354898
Web of Science ID: 178394800054
URI: http://researchonline.lshtm.ac.uk/id/eprint/17350

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