Genetic diversity and antigenic polymorphism in Plasmodium falciparum: Extensive serological cross-reactivity between allelic variants of merozoite surface protein 2


Franks, S; Baton, L; Tetteh, K; Tongren, E; Dewin, D; Akanmori, BD; Koram, KA; Ranford-Cartwright, L; Riley, EM; (2003) Genetic diversity and antigenic polymorphism in Plasmodium falciparum: Extensive serological cross-reactivity between allelic variants of merozoite surface protein 2. Infection and immunity, 71 (6). pp. 3485-3495. ISSN 0019-9567 DOI: https://doi.org/10.1128/iai.71.6.3485-3495.2003

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Abstract

Diversity in the surface antigens of malaria parasites is generally assumed to be a mechanism for immune evasion, but there is little direct evidence that this leads to evasion of protective immunity. Here we show that alleles of the highly polymorphic merozoite surface protein 2 (MSP-2) can be grouped (within the known dimorphic families) into distinct serogroups; variants within a serogroup show extensive serological cross- reactivity. Cross-reactive epitopes are immunodominant, and responses to them may be boosted at the expense of responses to novel epitopes (original antigenic sin). The data imply that immune selection explains only some of the diversity in the msp-2 gene and that MSP-2 vaccines may need to include only a subset of the known variants in order to induce pan-reactive antibodies.

Item Type: Article
Keywords: Polymerase-chain-reaction, circumsporozoite protein, natural-, selection, malaria antigens, serum antibodies, recognition, immunity, infections, children, vaccine, Alleles, Amino Acid Sequence, Animal, Antigens, Protozoan, chemistry, genetics, immunology, Cloning, Molecular, Cross Reactions, Molecular Sequence Data, Plasmodium falciparum, genetics, immunology, Polymorphism (Genetics), Protozoan Proteins, chemistry, genetics, immunology, Support, Non-U.S. Gov't, Variation (Genetics)
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 12761133
Web of Science ID: 183116300061
URI: http://researchonline.lshtm.ac.uk/id/eprint/17345

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