Protective efficacy of the RTS,S/AS02 Plasmodium falciparum malaria vaccine is not strain specific


Alloueche, A; Milligan, P; Conway, DJ; Pinder, M; Bojang, K; Doherty, T; Tornieporth, N; Cohen, J; Greenwood, BM; (2003) Protective efficacy of the RTS,S/AS02 Plasmodium falciparum malaria vaccine is not strain specific. The American journal of tropical medicine and hygiene, 68 (1). pp. 97-101. ISSN 0002-9637

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Abstract

RTS,S/AS02 is a recombinant protein malaria vaccine that contains a large portion of the C-terminal of the circumsporozoite protein (CSP) sequence of the NF54 isolate of Plasmodium falciparum fused to the hepatitis B virus surface antigen. It has been shown to induce significant protection to challenge infection with a homologous parasite strain in American volunteers. In a recently completed trial in semi-immune Gambian adults, vaccine efficacy against natural infection was 34% (95% confidence interval = 8-53%, P = 0.014) during the malaria season following vaccination. Breakthrough P. falciparum parasites sampled from vaccinated subjects and from controls were genotyped at two polymorphic regions of the csp gene encoding T cell epitopes (csp-th2r and csp-th3r) to determine if the vaccine conferred a strain-specific effect. The overall distribution of csp allelic variants was similar in infections occurring in vaccine and control groups. Also, the mean number of genotypes per infection in the RTS,S/AS02 group was not reduced compared with the controls.

Item Type: Article
Keywords: Adolescent, Adult, Animal, DNA, Protozoan/analysis, Epitopes/genetics, Gene Frequency, Genetic Markers, Genotype, Hepatitis B Surface Antigens/immunology, Human, *Malaria Vaccines, Malaria, Falciparum/*prevention & control, Male, Middle Age, Plasmodium falciparum/genetics/*immunology, Poisson Distribution, Polymorphism (Genetics), Protozoan Proteins/genetics/immunology, Support, Non-U.S. Gov't, Vaccines, Synthetic, Variation (Genetics), Adolescent, Adult, Animal, DNA, Protozoan, analysis, Epitopes, genetics, Gene Frequency, Genetic Markers, Genotype, Hepatitis B Surface Antigens, immunology, Human, Malaria Vaccines, Malaria, Falciparum, prevention & control, Male, Middle Age, Plasmodium falciparum, genetics, immunology, Poisson Distribution, Polymorphism (Genetics), Protozoan Proteins, genetics, immunology, Support, Non-U.S. Gov't, Vaccines, Synthetic, Variation (Genetics)
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Malaria Centre
Vaccine Centre
Tropical Epidemiology Group
PubMed ID: 12556156
Web of Science ID: 180253200018
URI: http://researchonline.lshtm.ac.uk/id/eprint/17066

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