Does apolipoprotein E polymorphism influence susceptibility to malaria?


Wozniak, MA; Faragher, EB; Todd, JA; Koram, KA; Riley, EM; Itzhaki, RF; (2003) Does apolipoprotein E polymorphism influence susceptibility to malaria? Journal of medical genetics, 40 (5). pp. 348-351. ISSN 0022-2593 DOI: https://doi.org/10.1136/jmg.40.5.348

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Abstract

Outcome of infection varies greatly among people, and in the case of three very different viruses, it is determined by apolipoprotein E (APOE) genotype. APOE might affect outcome of malaria infection also, since apoE protein and the protozoon (like the viruses) share cell entry mediators (heparan sulphate proteoglycans and/or specific apoE receptors). APOE polymorphisms give rise to protein variants that differ in binding strength to these mediators; thus, the extent of competition between apoE and protozoon for cell entry, and hence magnitude of protozoan damage, might depend on apoE isoform. Genotypes of infants infected with malaria were examined. It was found that APOE epsilon2 homozygotes became infected at an earlier age than those carrying the other genotypes, the difference being statistically significant. Parasite densities, all of which were low, did not differ significantly. This effect, although based on small numbers, suggests that APOE epsilon2 may be a risk factor for early infection.

Item Type: Article
Keywords: Herpes-simplex virus, hepatitis-c virus, heparan-sulfate, circumsporozoite protein, alzheimers-disease, infections, receptor, binding, glycosaminoglycans, genotype
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Population Studies (1974-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre: Malaria Centre
Population Studies Group
PubMed ID: 12746397
Web of Science ID: 182823500008
URI: http://researchonline.lshtm.ac.uk/id/eprint/17031

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