Effects of Temperature and Relative Humidity on DNA Methylation.


Bind, MA; Zanobetti, A; Gasparrini, A; Peters, A; Coull, B; Baccarelli, A; Tarantini, L; Koutrakis, P; Vokonas, P; Schwartz, J; (2014) Effects of Temperature and Relative Humidity on DNA Methylation. Epidemiology (Cambridge, Mass), 25 (4). pp. 561-9. ISSN 1044-3983 DOI: https://doi.org/10.1097/EDE.0000000000000120

Full text not available from this repository.

Abstract

BACKGROUND: Previous studies have found relationships between DNA methylation and various environmental contaminant exposures. Associations with weather have not been examined. Because temperature and humidity are related to mortality even on non-extreme days, we hypothesized that temperature and relative humidity may affect methylation.<br/> METHODS: We repeatedly measured methylation on long interspersed nuclear elements (LINE-1), Alu, and 9 candidate genes in blood samples from 777 elderly men participating in the Normative Aging Study (1999-2009). We assessed whether ambient temperature and relative humidity are related to methylation on LINE-1 and Alu, as well as on genes controlling coagulation, inflammation, cortisol, DNA repair, and metabolic pathway. We examined intermediate-term associations of temperature, relative humidity, and their interaction with methylation, using distributed lag models.<br/> RESULTS: Temperature or relative humidity levels were associated with methylation on tissue factor (F3), intercellular adhesion molecule 1 (ICAM-1), toll-like receptor 2 (TRL-2), carnitine O-acetyltransferase (CRAT), interferon gamma (IFN-γ), inducible nitric oxide synthase (iNOS), and glucocorticoid receptor, LINE-1, and Alu. For instance, a 5°C increase in 3-week average temperature in ICAM-1 methylation was associated with a 9% increase (95% confidence interval: 3% to 15%), whereas a 10% increase in 3-week average relative humidity was associated with a 5% decrease (-8% to -1%). The relative humidity association with ICAM-1 methylation was stronger on hot days than mild days.<br/> CONCLUSIONS: DNA methylation in blood cells may reflect biological effects of temperature and relative humidity. Temperature and relative humidity may also interact to produce stronger effects.<br/>

Item Type: Article
Faculty and Department: Faculty of Public Health and Policy > Dept of Social and Environmental Health Research
Research Centre: Centre for Statistical Methodology
Related URLs:
PubMed ID: 24809956
Web of Science ID: 337316700014
URI: http://researchonline.lshtm.ac.uk/id/eprint/1701224

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
326Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item