Clinical outcomes following percutaneous magnetic resonance image guided laser ablation of symptomatic uterine fibroids


Hindley, JT; Law, PA; Hickey, M; Smith, SC; Lamping, DL; Gedroyc, WMW; Regan, L; (2002) Clinical outcomes following percutaneous magnetic resonance image guided laser ablation of symptomatic uterine fibroids. Human reproduction (Oxford, England), 17 (10). pp. 2737-41. ISSN 0268-1161 DOI: https://doi.org/10.1093/humrep/17.10.2737

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Abstract

BACKGROUND: Fibroids are common benign tumours of the uterus. Percutaneous magnetic resonance (MR) image guided laser ablation provides a minimally invasive, day-case alternative to surgery for the treatment of symptomatic fibroids. METHODS: Women with symptomatic fibroids wishing to avoid surgery were treated with laser ablation. MR thermal mapping ensured that maximal safe energy was applied. Fibroid volume was measured at 3 and 12 months, menstrual blood loss was recorded before and after treatment and a menorrhagia outcomes questionnaire (MOQ) was used to assess satisfaction. RESULTS: A total of 66 patients was treated. There was a significant (P < 0.001) reduction in mean fibroid volume of 31%. This was 41% at 1 year follow-up (P < 0.001). Measured menstrual blood loss in eight patients complaining of excessive bleeding was reduced (P = 0.012). The MOQ total outcome score was not as good as that seen in hysterectomy patients (P = 0.02) but the quality of life/satisfaction score was similar (P = 0.06). CONCLUSION: We have used objective and subjective outcome measures to determine the efficacy of MR guided laser ablation for fibroids. Based on this limited study we are encouraged that this procedure may represent a minimally invasive alternative therapy for fibroids.

Item Type: Article
Keywords: fibroid, laser, MRI, outcomes, treatments, Nd-yag laser, hysterectomy, leiomyomas
Faculty and Department: Faculty of Public Health and Policy > Dept of Health Services Research and Policy
PubMed ID: 12351555
Web of Science ID: 179726200039
URI: http://researchonline.lshtm.ac.uk/id/eprint/16941

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