Prolonged measles virus shedding in human immunodeficiency virus-infected children, detected by reverse transcriptase- polymerase chain reaction


Permar, SR; Moss, WJ; Ryon, JJ; Monze, M; Cutts, F; Quinn, TC; Griffin, DE; (2001) Prolonged measles virus shedding in human immunodeficiency virus-infected children, detected by reverse transcriptase- polymerase chain reaction. The Journal of infectious diseases, 183 (4). pp. 532-8. ISSN 0022-1899

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Abstract

A reverse transcriptase-polymerase chain reaction assay was used to detect measles virus RNA in peripheral blood mononuclear cells, urine, and nasopharyngeal specimens from Zambian children during hospitalization and approximately 1-2 months after discharge. Of 47 children, 29 (61.7%) had prolonged measles virus shedding, as defined by detection of measles virus RNA in > or =1 specimen obtained 30-61 days after rash onset. Ten (90.9%) of 11 human immunodeficiency virus (HIV)-infected children had prolonged measles virus shedding, compared with 19 (52.8%) of 36 HIV-uninfected children (P=.02). Prolonged measles virus shedding did not correlate with levels of measles virus-specific antibody. HIV-infected children with measles may have a prolonged infectious period that potentially enhances measles virus transmission and hinders measles control.

Item Type: Article
Keywords: Dependent cellular cytotoxicity, immune-responses, clinical-, samples, antibody, mortality, viremia, antigen, adults, cells, rna, Adolescence, Antibodies, Viral, blood, Child, Child, Preschool, Female, HIV Infections, complications, HIV Seronegativity, HIV-1, isolation & purification, Human, Infant, Leukocytes, Mononuclear, virology, Male, Measles, complications, virology, Measles virus, genetics, immunology, isolation & purification, physiology, Nasopharynx, virology, RNA, Viral, analysis, Reverse Transcriptase Polymerase Chain Reaction, Support, Non-U.S. Gov't, Support, U.S. Gov't, P.H.S., Time Factors, Urine, virology, Virus Shedding, physiology, Zambia
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 11170977
Web of Science ID: 166586000002
URI: http://researchonline.lshtm.ac.uk/id/eprint/16909

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