Randomized, controlled trial of single versus 3-times-daily ferrous sulfate drops for treatment of anemia
Zlotkin, S; Arthur, P; Antwi, KY; Yeung, G; (2001) Randomized, controlled trial of single versus 3-times-daily ferrous sulfate drops for treatment of anemia. Pediatrics, 108 (3). pp. 613-6. ISSN 0031-4005Full text not available from this repository.
OBJECTIVE: Adherence to treatment of iron-deficiency anemia often is poor in both developed and developing countries. The current standard therapy is ferrous sulfate drops (or syrup) administered 3 times daily. It is possible that adherence would improve with a single-dose daily treatment regimen. We compared the use of single versus 3-times-daily ferrous sulfate drops, at the same total iron dose, on treatment of anemia in infants. METHODS: To obtain a large enough cohort of anemic subjects, we performed the study in rural Ghana. Using a prospective, randomized, controlled design, we studied 557 anemic children (age range: 6-24 months; hemoglobin values: 70-99 g/L). One group (n = 280) received ferrous sulfate drops once daily (40 mg elemental iron), and the control group (n = 277) received ferrous sulfate drops 3 times per day (total dose, 40 mg elemental iron). Treatment lasted for 2 months. Hemoglobin and serum ferritin values were measured at baseline and at the end of the study. RESULTS: Successful treatment of anemia (hemoglobin >100 g/L) occurred in 61% of the single-dose and in 56% of the 3-times-daily group. Geometric mean ferritin levels increased significantly in each group from baseline to the final visit. Side effects were minimal and similar between the 2 groups. CONCLUSION: A single versus a 3-times-daily dose of ferrous sulfate drops over 2 months resulted in a similar rate of successful treatment of anemia, without side effects. To our knowledge, this is the first demonstration of the use of a single-dose daily regimen to treat anemia. Although not examined in the current study, use of a single-dose daily regimen may improve adherence to treatment of anemia in infants.
|Keywords:||iron, ferrous sulfate drops, anemia, randomized controlled, trial, single versus 3-times-daily treatment, Iron supplementation, malaria, deficiency, children, ferritin, infants, Anemia, Iron-Deficiency, blood, drug therapy, Child, Preschool, Comparative Study, Drug Administration Schedule, Female, Ferritin, blood, Ferrous Compounds, administration & dosage, Hemoglobins, analysis, Human, Infant, Male, Patient Compliance, Prospective Studies, Support, Non-U.S. Gov't, Support, U.S. Gov't, Non-P.H.S.|
|Web of Science ID:||170781500024|
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