Serological Assays for HIV-Associated Tuberculosis in Sub-Saharan Africa?


Lawn, SD; (2014) Serological Assays for HIV-Associated Tuberculosis in Sub-Saharan Africa? Clinical and vaccine immunology, 21 (6). pp. 787-90. ISSN 1556-6811 DOI: https://doi.org/10.1128/CVI.00201-14

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Abstract

: In this issue of Clinical and Vaccine Immunology, Siev and colleagues present an evaluation of antibody responses to four immunodominant proteins of Mycobacterium tuberculosis in patients with HIV-associated pulmonary tuberculosis (TB) in South Africa (M. Siev, D. Wilson, S. Kainth, V. O. Kasprowicz, C. M. Feintuch, E. Jenny-Avital, and J. J. Achkar, 21:791-798, 2014, doi:http://dx.doi.org/10.1128/CVI.00805-13). This commentary discusses the enormous need for simple point-of-care assays for tuberculosis (TB) diagnosis in patients with and without HIV coinfection in high-burden settings and considers the potential role of serological assays and the huge challenges inherent in developing and validating such assays.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: TB Centre
PubMed ID: 24739979
Web of Science ID: 337352500001
URI: http://researchonline.lshtm.ac.uk/id/eprint/1673637

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