Tuberculosis contacts but not patients have higher gamma interferon responses to ESAT-6 than do community controls in The Gambia


Vekemans, J; Lienhardt, C; Sillah, JS; Wheeler, JG; Lahai, GP; Doherty, MT; Corrah, T; Andersen, P; McAdam, K; Marchant, A; (2001) Tuberculosis contacts but not patients have higher gamma interferon responses to ESAT-6 than do community controls in The Gambia. Infection and immunity, 69 (10). pp. 6554-6557. ISSN 0019-9567 DOI: https://doi.org/10.1128/IAI.69.10.6554-6557.2001

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Abstract

The Mycobacterium tuberculosis antigen ESAT-6 has been proposed for tuberculosis immunodiagnosis. In The Gambia, 30% of community controls produced gamma interferon (IFN-gamma) in response to ESAT-6. Increased proportions of responders and intensities of responses were found in household contacts. Responses that were initially low in tuberculosis patients increased after treatment. An ESAT-6 IFN-gamma assay will be of limited use in the diagnosis of tuberculosis in countries where tuberculosis is endemic. Its role in contact tracing should be evaluated further.

Item Type: Article
Keywords: T-cell responses, mycobacterium-tuberculosis, mortality, Adolescence, Adult, Antigens, Bacterial, immunology, pharmacology, Biological Markers, Cells, Cultured, Community-Acquired Infections, immunology, Endemic Diseases, Female, Gambia, epidemiology, Human, Interferon Type II, blood, Leukocytes, Mononuclear, cytology, drug effects, immunology, Male, Middle Age, Mycobacterium tuberculosis, immunology, Prospective Studies, Support, Non-U.S. Gov't, Tuberculin Test, Tuberculosis, Pulmonary, blood, epidemiology, immunology, transmission
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 11553606
Web of Science ID: 171121100076
URI: http://researchonline.lshtm.ac.uk/id/eprint/16431

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