Gaynor, Bruce D; Amza, Abdou; Kadri, Boubacar; Nassirou, Baido; Lawan, Ousmane; Maman, Laouali; Stoller, Nicole E; Yu, Sun N; Chin, Stephanie A; West, Sheila K; +5 more... Bailey, Robin L; Rosenthal, Philip J; Keenan, Jeremy D; Porco, Travis C; Lietman, Thomas M; (2014) Impact of mass azithromycin distribution on malaria parasitemia during the low-transmission season in Niger: a cluster-randomized trial. The American journal of tropical medicine and hygiene, 90 (5). pp. 846-851. ISSN 0002-9637 DOI: https://doi.org/10.4269/ajtmh.13-0379
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Abstract
We assessed the effect of mass azithromycin treatment on malaria parasitemia in a trachoma trial in Niger. Twenty-four study communities received treatment during the wet, high-transmission season. Twelve of the 24 communities were randomized to receive an additional treatment during the dry, low-transmission season. Outcome measurements were conducted at the community-level in children < 1-72 months of age in May-June 2011. Parasitemia was higher in the 12 once-treated communities (29.8%, 95% confidence interval [CI] = 21.5-40.0%) than in the 12 twice-treated communities (19.5%, 95% CI = 13.0-26.5%, P = 0.03). Parasite density was higher in once-treated communities (354 parasites/μL, 95% CI = 117-528 parasites/μL) than in twice-treated communities (74 parasites/μL, 95% CI = 41-202 parasites/μL, P = 0.03). Mass distribution of azithromycin reduced malaria parasitemia 4-5 months after the intervention. The results suggest that drugs with antimalaria activity can have long-lasting impacts on malaria during periods of low transmission.
Item Type | Article |
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Faculty and Department | Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
Research Centre | Malaria Centre |
PubMed ID | 24615132 |
ISI | 335707600015 |
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Filename: Impact of Mass Azithromycin Distribution_GREEN VoR.pdf
Licence: Creative Commons: Attribution-Noncommercial-No Derivative Works 3.0
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