Incidence and risk factors of paediatric rotavirus diarrhoea in northern Ghana


Binka, FN; Anto, FK; Oduro, AR; Awini, EA; Nazzar, AK; Armah, GE; Asmah, RH; Hall, AJ; Cutts, F; Alexander, N; Brown, D; Green, J; Gray, J; Iturriza-Gomara, M; (2003) Incidence and risk factors of paediatric rotavirus diarrhoea in northern Ghana. Tropical medicine & international health , 8 (9). pp. 840-6. ISSN 1360-2276

Full text not available from this repository.

Abstract

We measured the type-specific incidence of paediatric rotavirus diarrhoea in an area of northern Ghana. Over 1 year, diarrhoea 1717 episodes were identified, of which 677 (39%) were positive for rotavirus. Risk factors for rotavirus infection included old age, wasting, high Vesikari score and the episode occurring in the dry season. Rotavirus-positive episodes tended to be more acute, causing vomiting and greater dehydration, and were more likely to require hospitalization. The incidence was 0.089 episodes per person-year for all diarrhoea, and 0.035 for rotavirus diarrhoea. The observed incidence decreased markedly with distance from the nearest health centre, suggesting a large unobserved burden. G2P[6], G3P[4] and G9P[8] made up more than half the genotypes detected, but the remainder were diverse. There is a large burden of rotavirus diarrhoea, but the effectiveness of future vaccines could be diluted by the high polymorphism of the virus, and the difficulty of reaching remote populations.

Item Type: Article
Keywords: rotavirus, diarrhoea, incidence, risk factors, burden, Ghana, Polymerase-chain-reaction, united-kingdom, diversity, disease, epidemiology, immunization, children, strains, vaccine
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Tropical Epidemiology Group
PubMed ID: 12950670
Web of Science ID: 185080200010
URI: http://researchonline.lshtm.ac.uk/id/eprint/15877

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
340Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item