Measuring the accuracy of a point system to diagnose tuberculosis in children with a negative smear or with no smear or culture.


Cartaxo, CG; Rodrigues, LC; Braga, CP; Ximenes, RA; (2013) Measuring the accuracy of a point system to diagnose tuberculosis in children with a negative smear or with no smear or culture. Journal of epidemiology and global health, 4 (1). pp. 29-34. ISSN 2210-6006 DOI: 10.1016/j.jegh.2013.10.002

Full text not available from this repository.

Abstract

In Brazil, a scoring system was adopted to diagnose tuberculosis in childhood. This study determined the accuracy in diagnosing tuberculosis in children with either a negative smear or with no smear or culture conducted in a reference center in João Pessoa Paraíba - Brazil. It is a phase III validation study, using a cross-section design. The study population consisted of 167 patients attending the outpatient clinics suspected of having tuberculosis. The reference standard for the diagnosis of tuberculosis was a blind and independent review of the medical records, radiology and tuberculin test by two experts. Of the 167 patients, 60 were considered to have tuberculosis (by the reference standard diagnostics). The results for the scoring system with the cut-off of 30 points were: sensitivity 78.57% (95%-CI: 65.56-88.41%), specificity 69.16% (95%-CI: 59.50-77.73%), positive predictive value (PPV): 57.14% (95%-CI: 45.35-68.37%), negative predictive value (NPV): 86.05% (95%-CI: 76.89-92.58%), likelihood ratio (+): 2,55, pre-test probability: 34.36%, and post-test probability (+): 57.14%. This supports the current recommendation for the use of this scoring system in Brazil and similar sites with the cut-off of 30 points. However, as the discriminatory power of the point scoring system may vary across settings, it would be advisable to replicate this phase III study in different settings.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 24534333
URI: http://researchonline.lshtm.ac.uk/id/eprint/1559942

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
269Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item