A randomised trial to compare the safety, tolerability and efficacy of three drug combinations for intermittent preventive treatment in children.


Bojang, K; Akor, F; Bittaye, O; Conway, D; Bottomley, C; Milligan, P; Greenwood, B; (2010) A randomised trial to compare the safety, tolerability and efficacy of three drug combinations for intermittent preventive treatment in children. PLoS One, 5 (6). e11225. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0011225

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Abstract

Results from trials of intermittent preventive treatment (IPT) in infants and children have shown that IPT provides significant protection against clinical malaria. Sulfadoxine-pyrimethamine (SP) given alone or in combination with other drugs has been used for most IPT programmes. However, SP resistance is increasing in many parts of Africa. Thus, we have investigated whether SP plus AQ, SP plus piperaquine (PQ) and dihydroartemisinin (DHA) plus PQ might be equally safe and effective when used for IPT in children in an area of seasonal transmission.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Malaria Centre
Centre for Maternal, Reproductive and Child Health (MARCH)
Tropical Epidemiology Group
PubMed ID: 20574538
Web of Science ID: 279058300015
URI: http://researchonline.lshtm.ac.uk/id/eprint/1556

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