Variation in Toll-like receptor 4 and susceptibility to group A meningococcal meningitis in Gambian children.
Allen, Angela;
Obaro, Stephen;
Bojang, Kalifa;
Awomoyi, Agnes A;
Greenwood, Brian M;
Whittle, Hilton;
Sirugo, Giorgio;
Newport, Melanie J;
(2003)
Variation in Toll-like receptor 4 and susceptibility to group A meningococcal meningitis in Gambian children.
The Pediatric infectious disease journal, 22 (11).
pp. 1018-1019.
ISSN 0891-3668
DOI: https://doi.org/10.1097/01.inf.0000095431.15606.68
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
Meningitis is an important cause of childhood mortality in sub-Saharan Africa. A case-control study investigating the role of the Toll-like receptor 4 gene in host susceptibility to Group A Neisseria meningitidis meningitis was conducted in 524 Gambian children. There was no association between a functional Toll-like receptor 4 gene polymorphism and meningitis, suggesting that this variant is not a major determinant of disease in this population.
