Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20-44 years: the UK National Case-Control Study of Cervical Cancer


Green, J; Berrington de Gonzalez, A; Sweetland, S; Beral, V; Chilvers, C; Crossley, B; Deacon, J; Hermon, C; Jha, P; Mant, D; Peto, J; Pike, M; Vessey, MP; (2003) Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20-44 years: the UK National Case-Control Study of Cervical Cancer. British journal of cancer, 89 (11). pp. 2078-86. ISSN 0007-0920 DOI: https://doi.org/10.1038/sj.bjc.6601296

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Abstract

We report results on risk factors for invasive squamous cell and adenocarcinomas of the cervix in women aged 20-44 years from the UK National Case-Control Study of Cervical Cancer, including 180 women with adenocarcinoma, 391 women with squamous cell carcinoma and 923 population controls. The risk of both squamous cell and adenocarcinoma was strongly related to the lifetime number of sexual partners, and, independently, to age at first intercourse. The risk of both types of cervical cancer increased with increasing duration of use of oral contraceptives, and this effect was most marked in current and recent users of oral contraceptives. The risk of squamous cell carcinoma was associated with high parity and the risk of both squamous cell and adenocarcinoma increased with early age at first birth. Long duration smoking (20 or more years) was associated with a two-fold increase in the risk of squamous cell carcinoma, but smoking was not associated with the risk of adenocarcinoma. Further studies are needed to confirm the suggestion from this and other studies of differences in risk related to smoking between squamous cell and adenocarcinomas of the cervix.British Journal of Cancer (2003) 89, 2078-2086. doi:10.1038/sj.bjc.6601296 www.bjcancer.com

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 14647141
Web of Science ID: 187490500011
URI: http://researchonline.lshtm.ac.uk/id/eprint/15439

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