Sensilidade e especificidade da leitura da cicatriz vacinol do BCG [Sensitivity and specificity of the BCG scar reading]


Pereira, SM; Bierrenbach, AL; Dourado, I; Barreto, ML; Ichihara, MY; Hijjar, MA; Rodrigues, LC; (2003) Sensilidade e especificidade da leitura da cicatriz vacinol do BCG [Sensitivity and specificity of the BCG scar reading]. Revista de saude publica, 37 (2). pp. 254-9. ISSN 0034-8910 DOI: https://doi.org/10.1590/S0034-89102003000200015

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Abstract

OBJECTIVE: To validate the BCG scar as a marker of BCG vaccination status. METHODS: A cross-sectional survey was carried out among 53,348 schoolchildren aged 6-14 years who underwent BCG scar examination as part of a large BCG vaccine trial taking place in the city of Manaus, Brazil. Results of BCG scar reading were compared with information on vaccine status of their vaccination cards or provided by parents or guardians. Double-reading was performed in a sub-sample. Data analysis was conducted using Stata 7 and Kappa coefficient. RESULTS: Of 52,348 schoolchildren studied, vaccine status information from parents/guardian letters was available for 29,254 and from vaccination cards for 4,947. There was found a high agreement between the double-readings of the scars (Kappa=0.81). When the agreement between letter and card information was the gold standard, the sensitivity of BCG scar readings was 96.6% (95%CI 96.0-97.1) and the specificity was 71.1% (95%CI 55.7-83.7). The sensitivity was 96.1%, 97.3% and 95.3% for children vaccinated up to one month of age, four months and one year, respectively. CONCLUSIONS: Sensitivity and specificity did not show an association with the child's age at the scar reading. BCG scar was a good marker of BCG vaccination status regardless of age - from the first years of life up to 14 years old.

Item Type: Article
Keywords: Adolescent, Age Distribution, Age Factors, BCG Vaccine/*administration & dosage, Brazil, Child, *Cicatrix, Cross-Sectional Studies, English Abstract, Female, Follow-Up Studies, Human, Immunization/*statistics & numerical data, Immunization Schedule, Male, Sensitivity and Specificity, Tuberculosis/*prevention & control, Vaccination/utilization, Adolescent, Age Distribution, Age Factors, BCG Vaccine, administration & dosage, Brazil, Child, Cicatrix, Cross-Sectional Studies, English Abstract, Female, Follow-Up Studies, Human, Immunization, statistics & numerical data, Immunization Schedule, Male, Sensitivity and Specificity, Tuberculosis, prevention & control, Vaccination, utilization
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 12700850
Web of Science ID: 221312100015
URI: http://researchonline.lshtm.ac.uk/id/eprint/15054

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