Advances in mode of action of antimalarials and resistance mechanisms - part 1 of 2


Warhurst, DC; (2013) Advances in mode of action of antimalarials and resistance mechanisms - part 1 of 2.

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Abstract

1. Introduction 2. Life cycle stage as drug target 3. Malaria parasite in red blood cell 4. Action of antiplasmodial drugs 5. Chloroquine base is trapped in acidic DV 6. Targets other than DV 7. Sdx and Pyr targets in the folate synthesis cycle 8. Resistance to sulfadoxine and pyrimethamine 9. Mitochondrial compartment 10. CoQ8 and atovaquone similarity 11. Cytochrome B wild type vs. mutant 12. Apicoplast 13. Cultured pre-erythrocytic schizont of P. berghei 14. CQ, QN, mefloquine, artemisinin & analogues 15. Sweet wormwood (Artemisia annua) (1) 16. Sweet wormwood (Artemisia annua) (2) 17. Artemisinin structure and metabolism 18. Artemisinin mode of action 19. Evidence for drug activation 20. END

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Antimicrobial Resistance Centre (AMR)
Malaria Centre
URI: http://researchonline.lshtm.ac.uk/id/eprint/1496146

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