Design of the Leprosy Component of the Brazilian BCG Revaccination Trial for Assessing BCG Effectiveness against Leprosy in School Children.


Cunha, SS; Dourado, I; Barreto, ML; Alexander, N; Pereira, SM; Ichihara, Y; Pereira, ES; Pedrosa, V; Maroja, F; Ribas, C; Rodrigues, LC; (2004) Design of the Leprosy Component of the Brazilian BCG Revaccination Trial for Assessing BCG Effectiveness against Leprosy in School Children. International journal of leprosy and other mycobacterial diseases , 72 (1 ). 8-15 . ISSN 0148-916X DOI: 10.1489/1544-581X(2004)072<0008:DOTLCO>2.0.CO;2

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Abstract

Background. BCG vaccination confers protection against leprosy, and vaccination among household contacts has been recommended in Brazil. Nevertheless, vaccination of the entire community against leprosy is not advocated as leprosy has low incidence in most populations. Despite that, in Brazil, BCG vaccination is recommended among school children to prevent tuberculosis and this large scale vaccination may also affect the occurrence of leprosy, which led to investigations of its impact on leprosy in endemic areas of Brazil.Objectives. To estimate the effectiveness against leprosy of a dose of BCG vaccine given to school children in a population with a high coverage of neonatal BCG. Long term objectives are to compare the impact of vaccination among schoolchildren with the existing recommendation to vaccinate household contacts of leprosy.Study design. Cluster randomized controlled field trial with no placebo.Study population. Children aged 7 to 14 years attending state schools with high coverage of neonatal BCG.Methods. 286 state schools in the city of Manaus, Brazil, were randomized to receive BCG or not. Identifying information was collected for 152,438 school children, of whom 72,980 are in intervention schools. BCG vaccination was given intradermically to children in schools allocated to vaccination. Follow-up relies on ascertainement of cases diagnosed at the health services and notified to the reference center for leprosy.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
Centre for Global Non-Communicable Diseases (NCDs)
Vaccine Centre
Tropical Epidemiology Group
PubMed ID: 15217320
Web of Science ID: 222052300002
URI: http://researchonline.lshtm.ac.uk/id/eprint/14626

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