Age influences resistance of Caenorhabditis elegans to killing by pathogenic bacteria


Laws, TR; Harding, SV; Smith, MP; Atkins, TP; Titball, RW; (2004) Age influences resistance of Caenorhabditis elegans to killing by pathogenic bacteria. FEMS microbiology letters, 234 (2). p. 281. ISSN 0378-1097 DOI: 10.1016/j.femsle.2004.03.034

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Abstract

Caenorhabditis elegans has previously been proposed as an alternative host for models of infectious disease caused by human pathogens. When exposed to some human pathogenic bacteria, the life span of nematodes is significantly reduced. We have shown that mutations in the age-1, and/or age-2 genes of C elegans, that normally enhance life expectancy, can also increase resistance to killing by the bacterial pathogens Pseudomonas aeruginosa, Salmonella enterica var. Typhimurium, Burkholderia cepacia or Yersinia pseudotuberculosis. We also found that the rate at which wild-type C elegans was killed by the bacterial pathogens tested increased as nematodes aged. In the case of P. aeruginosa infection, the difference in life span of wild type and age-1 mutants of C elegans was not due to differences in the level of bacterial colonisation of the gut. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: Camorhabditis elegans, pathogenic bacteria, alternative model, Heat-shock proteins, burkholderia-cepacia, life-span, salmonella-typhimurium, virulence factors, reactive oxygen, model host, longevity, mutants, system
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 15135534
Web of Science ID: 221516100013
URI: http://researchonline.lshtm.ac.uk/id/eprint/14618

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