Community-based randomized double-blind study of gastrointestinal effects and copper exposure in drinking water.


Araya, M; Olivares, M; Pizarro, F; Llanos, A; Figueroa, G; Uauy, R; (2004) Community-based randomized double-blind study of gastrointestinal effects and copper exposure in drinking water. Environmental health perspectives, 112 (10). pp. 1068-73. ISSN 0091-6765 DOI: https://doi.org/10.1289/ehp.6913

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Abstract

We assessed gastrointestinal effects in 1,365 adults exposed to either < 0.01 (controls), 2, 4, or 6 mg copper/L of drinking water for 2 months in a randomized, double-blind community-based study. The risk of symptoms increased with increasing Cu exposure and decreased with time. The best model by counting-process analysis included Cu concentration and sex. The risk of symptoms remained significantly higher in women than in men during weeks 1-4 for all concentrations tested; at week 1 comparison with the < 0.01-mg/L group showed that differences became significant in women at 4 mg/L [relative risk (RR) = 1.53; 95% confidence interval (CI), 1.02-2.05), and in men at 6 mg/L (RR = 1.9; 95% CI, 1.02-2.79). At week 2 for men and week 4 in women, the Cu concentration required to obtain significant differences on symptom report was > 6 mg Cu/L. We conclude that exposure to Cu in drinking water results in gastrointestinal symptoms, which are modulated by Cu concentration, time, and sex.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 15238279
Web of Science ID: 222482300026
URI: http://researchonline.lshtm.ac.uk/id/eprint/14585

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