MMR vaccination and pervasive developmental disorders: a case-control study.


Smeeth, L; Cook, C; Fombonne, E; Heavey, L; Rodrigues, LC; Smith, PG; Hall, AJ; (2004) MMR vaccination and pervasive developmental disorders: a case-control study. Lancet, 364 (9438). pp. 963-9. ISSN 0140-6736 DOI: 10.1016/S0140-6736(04)17020-7

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Abstract

BACKGROUND: Concern that measles-mumps-rubella (MMR) vaccination might cause autism has led to a fall in vaccine coverage. We investigated whether MMR vaccination is associated with an increased risk of autism or other pervasive developmental disorders. METHODS: We did a matched case-control study using the UK General Practice Research Database. Cases were people born in 1973 or later who had first recorded diagnosis of pervasive developmental disorder while registered with a contributing general practice between 1987 and 2001. Controls were matched on age, sex, and general practice. FINDINGS: 1294 cases and 4469 controls were included. 1010 cases (78.1%) had MMR vaccination recorded before diagnosis, compared with 3671 controls (82.1%) before the age at which their matched case was diagnosed. After adjustment for age at joining the database, the odds ratio for association between MMR and pervasive developmental disorder was 0.86 (95% CI 0.68-1.09). Findings were similar when restricted to children with a diagnosis of autism, to those vaccinated with MMR before the third birthday, or to the period before media coverage of the hypothesis linking MMR with autism. INTERPRETATION: Our findings suggest that MMR vaccination is not associated with an increased risk of pervasive developmental disorders.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
Vaccine Centre
Centre for Maternal, Reproductive and Child Health (MARCH)
PubMed ID: 15364187
Web of Science ID: 223831000026
URI: http://researchonline.lshtm.ac.uk/id/eprint/14398

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