Pharmaceutical interventions for mitigating an influenza pandemic: modeling the risks and health-economic impacts


Postma, MJ; Milne, G; Nelson, EAS; Pyenson, B; Basili, M; Coker, R; Oxford, J; Garrison, LP; (2010) Pharmaceutical interventions for mitigating an influenza pandemic: modeling the risks and health-economic impacts. Expert review of anti-infective therapy, 8 (12). pp. 1431-1439. ISSN 1478-7210 DOI: https://doi.org/10.1586/eri.10.136

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Abstract

Model-based analyses built on burden-of-disease and cost effectiveness theory predict that pharmaceutical interventions may efficiently mitigate both the epidemiologic and economic impact of an influenza pandemic. Pharmaceutical interventions typically encompass the application of (pre)pandemic influenza vaccines, other vaccines (notably pneumococcal), antiviral treatments and other drug treatment (e.g., antibiotics to target potential complications of influenza). However, these models may be too limited to capture the full macro-economic impact of pandemic influenza. The aim of this article is to summarize current health-economic modeling approaches to recognize the strengths and weaknesses of these approaches, and to compare these with more recently proposed alternative methods. We conclude that it is useful, particularly for policy and planning purposes, to extend modeling concepts through the application of alternative approaches, including insurers' risk theories, human capital approaches and sectoral and full macro-economic modeling. This article builds on a roundtable meeting of the Pandemic Influenza Economic Impact Group that was held in Boston, MA, USA, in December 2008.

Item Type: Article
Keywords: cost-effectiveness analysis, economic impact, pandemic influenza, COST-EFFECTIVENESS, UNITED-STATES, INFECTIOUS-DISEASES, VACCINATION, NETHERLANDS, EQUILIBRIUM, STRATEGIES, CHILDREN, SPREAD
Faculty and Department: Faculty of Public Health and Policy > Dept of Global Health and Development
PubMed ID: 21133667
Web of Science ID: 286039200015
URI: http://researchonline.lshtm.ac.uk/id/eprint/1389

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