Protective efficacy of a recombinant plague vaccine when co- administered with another sub-unit or live attenuated vaccine


Griffin, K; Bedford, R; Townson, K; Phillpotts, R; Funnell, S; Morton, M; Williamson, D; Titball, R; (2005) Protective efficacy of a recombinant plague vaccine when co- administered with another sub-unit or live attenuated vaccine. FEMS immunology and medical microbiology. p. 425. ISSN 0928-8244 DOI: 10.1016/j.femsim.2004.10.012

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Abstract

Vaccines against bioterrorism agents offer the prospect of providing high levels of protection against airborne pathogens. However, the diversity of the bioterrorism threat means that it may be necessary to use several vaccines simultaneously. In this study we have investigated whether there are changes to the protective immune response to a recombinant sub-unit plague vaccine when it is co-administered with other sub-unit or live attenuated vaccines. Our results indicate that the co- administration of these vaccines did not influence the protection afforded by the plague vaccine. However, the co- administration of the plague sub-unit vaccine with a live vaccine resulted in markedly increased levels of IgG2a subclass antibodies, and markedly reduced levels of IgG1 subclass antibodies, to the plague sub-unit vaccine. This finding might have implications when considering the co-administration of other vaccine combinations. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: co-administration, plague, vaccines, Hepatitis-a vaccine, equine encephalitis-virus, yellow-fever, vaccine, b conjugate vaccine, acellular pertussis, immune-, response, yersinia-pestis, ifn-gamma, multiple vaccines, t-, lymphocytes
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Vaccine Centre
PubMed ID: 15708318
Web of Science ID: 227532100015
URI: http://researchonline.lshtm.ac.uk/id/eprint/13827

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