Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.


Lindström, S; Vachon, CM; Li, J; Varghese, J; Thompson, D; Warren, R; Brown, J; Leyland, J; Audley, T; Wareham, NJ; Loos, RJ; Paterson, AD; Rommens, J; Waggott, D; Martin, LJ; Scott, CG; Pankratz, VS; Hankinson, SE; Hazra, A; Hunter, DJ; Hopper, JL; Southey, MC; Chanock, SJ; Silva, IdosS; Liu, J; Eriksson, L; Couch, FJ; Stone, J; Apicella, C; Czene, K; Kraft, P; Hall, P; Easton, DF; Boyd, NF; Tamimi, RM; (2011) Common variants in ZNF365 are associated with both mammographic density and breast cancer risk. Nature genetics, 43 (3). pp. 185-7. ISSN 1061-4036 DOI: https://doi.org/10.1038/ng.760

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Abstract

: High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 21278746
Web of Science ID: 287693800007
URI: http://researchonline.lshtm.ac.uk/id/eprint/1378

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