Plasmodium ovale curtisi and Plasmodium ovale wallikeri circulate simultaneously in African communities.


Oguike, MC; Betson, M; Burke, M; Nolder, D; Stothard, JR; Kleinschmidt, I; Proietti, C; Bousema, T; Ndounga, M; Tanabe, K; Ntege, E; Culleton, R; Sutherland, CJ; (2011) Plasmodium ovale curtisi and Plasmodium ovale wallikeri circulate simultaneously in African communities. International journal for parasitology, 41 (6). pp. 677-83. ISSN 0020-7519 DOI: https://doi.org/10.1016/j.ijpara.2011.01.004

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Abstract

: It has been proposed that ovale malaria in humans is caused by two closely related but distinct species of malaria parasite, Plasmodium ovale curtisi and Plasmodium ovale wallikeri. It was recently shown that these two parasite types are sympatric at the country level. However, it remains possible that localised geographic, temporal or ecological barriers exist within endemic countries which prevent recombination between the genomes of the two species. Here, using conventional and real-time quantitative PCR (qPCR) methods specifically designed to discriminate P. o. curtisi and P. o. wallikeri, it is shown that both species are present among clinic attendees in Congo-Brazzaville, and occur simultaneously both in lake-side and inland districts in Uganda and on Bioko Island, Equatorial Guinea. Thus P. o. curtisi and P. o. wallikeri in these localities are exactly sympatric in both time and space. These findings are consistent with the existence of a biological barrier, rather than geographical or ecological factors, preventing recombination between P. o. curtisi and P. o. wallikeri. In cross-sectional surveys carried out in Uganda and Bioko, our results show that infections with P. ovale spp. are more common than previously thought, occurring at a frequency of 1-6% in population samples, with both proposed species contributing to ovale malaria in six sites. Malaria elimination programmes in Africa need to include strategies for control of P. o. curtisi and P. o. wallikeri.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Infectious and Tropical Diseases
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Malaria Centre
Tropical Epidemiology Group
PubMed ID: 21315074
Web of Science ID: 291420800010
URI: http://researchonline.lshtm.ac.uk/id/eprint/1356

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